PUBLICATIONS

  1. C.L. Barkau, D. O’Reilly, K.J. Rohilla, M.J. Damha, and Keith T. Gagnon (2019). Rationally designed Anti-CRISPR nucleic acid inhibitors of CRISPR-Cas9 (Under review).
  2. M. Takahashi, H. Li, J. Zhou, V. Aishwarya, M.J. Damha, and J.J. Rossi (2019). Dual mechanism of action of self-delivering, anti-HIV-1 FANA oligonucleotides as a potential new approach to HIV therapy (Under review).
  3. A. Banerjee, A. Munir, L. Abdullahu, M.J. Damha, Y. Goldgur, and S. Shuman (2019). Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO4 recognition and splice junction ADP-ribosylation, Nature Communications. doi: 10.1038/s41467-018-08211-9
  4. D. O'Reilly, Z. Kartje, E. Ageely, E. Malek-Adamian, M. Habibian, A. Schofield, L. DeRossett, A. Weigle, M.J. Damha, and K. Gagnon (2018). Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity, Nucleic Acids Research, doi: 10.1093/nar/gky1214.
  5. J. Lietard, D. Ameur, M.J. Damha, and M.M. Somoza (2018). High-density microarrays synthesized in situ by photolithography. Angewandte Chemie Int. Ed. 57, 15257-1526. doi: 10.1002/anie.201806895
  6. J. Lietard, M.J. Damha, and M.M. Somoza (2018). Advances in light-directed synthesis of high-density microarrays and extension to RNA and 2′F-ANA chemistries. In "New Trends in Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives" (Wiley). doi:10.1002/9783527812103.ch11
  7. D. O'Reilly, R.S. Stein, M, Burai Patrascu, S. Kumar Jana, J, Kurian, N. Moitessier, and M.J. Damha (2018). Exploring atypical fluorine-hydrogen bonds and their effects on nucleoside conformations. Chemistry – A European Journal 24, 16432-16439. doi: 10.1002/chem.2018039
  8. H. Abou Assi, M. Garavís, C. González, M.J. Damha (2018). i-Motif DNA: Structural features and significance to cell biology. Nucleic Acids Research 46, 8038-8056. doi: 10.1093/nar/gky735
  9. E. Malek-Adamian, M. Burai Patrascu, S. Kumar Jana, S. Martínez-Montero, N. Moitessier and M.J. Damha (2018). Adjusting the structure of 2ʹ-modified nucleosides and oligonucleotides via C4ʹ-α-F or C4ʹ-α-OMe substitution: synthesis and conformational analysis. Journal of Organic Chemistry 83, 9839-9849. doi: 10.1021/acs.joc.8b01329
  10. X. Shen, A. Kilikevicius, D. O’Reilly, T. Prakash, F. Rigo, M.J. Damha, and D.R. Corey, (2018). Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion. Bioorganic & Medicinal Chemistry Letters 28, 2850-2855. doi: 10.1016/j.bmcl.2018.07.033
  11. A. Munir, L. Abdullahu, M. J. Damha, and S. Shuman. (2018). Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2'-phosphotransferase Tpt1. RNA 24, 1144-1157. doi: 10.1261/rna.067165.118
  12. D. Vlaho and M.J. Damha. (2018). Automated solid phase synthesis of phosphoramidate-modified oligonucleotides. Current Protocols in Nucleic Acid Chemistry 73(1), e53. doi: 10.1002/cpnc.53
  13. A. Arnold, E. Malek-Adamian, P. Le, A. Meng S. Martínez-Montero, K. Petrecca, M.J. Damha, and M. Shoichet (2018). Antibody-antisense oligonucleotide conjugate downregulates a key gene in glioblastoma stem cells. Molecular Therapy - Nucleic Acids 11, 518-527. doi: 10.1016/j.omtn.2018.04.004
  14. M. Habibian, M. Yahyaee Anzahaee, M. Lucic, E. Moroz, N. Martín-Pintado, L. DiGiovanni, J-C. Leroux, J. Hall,C. González, and M J. Damha (2018). Structural properties and gene-silencing activity of chemically modified DNA-RNA Hybrids with parallel orientation. Nucleic Acids Research 46, 1614-1623. doi: 10.1093/nar/gky024
  15. S.-Y. Zhang, N.E. Clark, C.A. Freije, E. Pauwels, A. Taggart, S. Okada, H. Mandel, P. Garcia, M.J. Ciancanelli, A. Biran, F.G. Lafaille, M. Tsumura, A. Cobat, J. Luo, S. Volpi, B. Zimmer, S. Sakata, A. Dinis, O. Ohara, E.J. Garcia Reino, K. Dobbs, M. Hasek, S.P. Holloway, K. McCammon, S.A. Hussong, N. DeRosa, L. Lorenzo, M. Hyodo, C.E. Van Skike, A. Katolik, E. Faria, R. Halwani, R. Fukuhara, V. Galvan, M.J. Damha, S. Al-Muhsen, Y. Itan, J.D. Boeke, L.D. Notarangelo, L. Studer, M. Kobayashi, L. Diogo, W. Fairbrother, L. Abel, B. Rosenberg, P.J. Hart, A. Etzioni, J.-L. Casanova (2018). Inborn errors of lariat metabolism in humans with viral infections on the brainstem. Cell 172, 952-956.e18. doi: 10.1016/j.cell.2018.02.019
  16. L. Li, X. Shen, Z. Liu, M. Norrbom, T.P. Prakash, D. O’Reilly, V. Sharma, M.J. Damha, J.K. Watts, F. Rigo, and D.R. Corey (2018). Activation of Frataxin expression by antisense oligonucleotides targeting the mutant expanded repeat. Nucleic Acid Therapeutics 28, 23-33. doi: 10.1089/nat.2017.0703
  17. D. Vlaho, J.F. Fakhoury and M.J. Damha (2018). Incorporation of cationic phosphoramidate linkages in siRNA: Thermal stability, structural studies, and activity. Nucleic Acid Therapeutics 28, 34-43. doi: 10.1089/nat.2017.0702
  18. H. Abou Assi, Y.C. Lin, I. Serrano, C. Gonzalez† and M.J. Damha† (2017). Probing synergistic effects of nucleobase 5-methylation and arabinose 2'-beta-fluorination on i-motif stability. Chemistry - A European Journal 24, 471-477. doi: 10.1002/chem.201704591
  19. E. Malek-Adamian, D.C. Guenther, S. Matsuda, S. Martínez-Montero, I. Zlatev, J. Harp, M. Burai Patrascu, D. Foster, J. Fakhoury, L. Perkins, N. Moitessier ,R.M. Manoharan, N. Taneja, A. Bisbe, K. Charisse, M. Maier, R.G. Kallanthottathil, Martin Egli, M. Manoharan and M.J. Damha (2017). 2′,4′-modified ribonucleotides improve metabolic stability and elicit efficient siRNA-mediated gene silencing. Journal of the American Chemical Society 139, 14542-14555. doi: 10.1021/jacs.7b07582
  20. M. Burai Patrascu, E. Malek-Adamian, M.J. Damha and N. Moitessier (2017). Accurately modelling the conformational preferences of nucleotides. Journal of the American Chemical Society 139, 13620-13623. doi: 10.1021/jacs.7b07436
  21. H. Abou Assi, C. Gonzalez,† and M.J. Damha (2017). 2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA. Nucleic Acids Research 45, 11535-11546. doi: 10.1093/nar/gkx838
  22. Y.M. Abbas, B. Theres Laudenbach, S. Martínez-Montero, R. Cencic, M. Habjan, A. Pichlmair, M.J. Damha, J. Pelletier and B. Nagar (2017). Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations. Proceedings of the National Academy of Science USA 114, 2106-2115. doi: 10.1073/pnas.1612444114
  23. J. Lietard, H. Abou-Assi, I. Gomez-Pinto, C. Gonzalez, M.M. Somoza and M.J. Damha (2017). Mapping the affinity landscape of thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-quadruplex microarrays. Nucleic Acids Research 45, 1619-1632. doi: 10.1093/nar/gkw1357
  24. >A. Katolik, N.E. Clark, N. Tago, E.J. Montemayor, P.J. Hart, and M.J. Damha (2017). Fluorescent branched RNAs for high-throughput analysis of Dbr1 enzyme kinetics and inhibition. ACS Chemical Biology 12, 622-627. doi: 10.1021/acschembio.6b00971
  25. N.E. Clark, A. Katolik, K. Roberts, A.B. Taylor, S.P. Holloway, E.J. Montemayor, S.W. Stevens, P.F. Fitzpatrick, M.J. Damha and P.J. Hart (2016). Structure, kinetics, and mechanism of the RNA lariat debranching enzyme Dbr1. Proceedings of the National Academy of Science USA 113, 14727-14732. doi: 10.1073/pnas.1612729114
  26. M. Hollestein† and M.J. Damha (2016). Rolling circle amplification with modified nucleoside triphosphates. Current Protocols in Nucleic Acid Chemistry 67, 7.26.1-15. doi: 10.1002/cpnc.17
  27. E. Moroz, S. Hyeon Lee, K. Yamada, F. Halloy, S. Martínez-Montero, H. Jahns, J. Hall, M.J. Damha, B. Castagner and J.-C. Leroux† (2016). Carrier-free gene silencing by amphiphilic nucleic acid conjugates in differentiated intestinal cells. Molecular Therapy - Nucleic Acids 5, e364. doi: 10.1038/mtna.2016.69
  28. H. Abou Assi, R.W. Harkness V, N. Martín-Pintado, C.J. Wilds, R. Campos-Olivas, A.K. Mittermaier, C. González† and M.J. Damha† (2016). Stabilization of i-motif structures by 2'-beta-fluorination of DNA. Nucleic Acids Research 44, 4998-5009. doi: 10.1093/nar/gkw402
  29. A. Kulkarni, M.J. Damha, R. Schinazi, H. Mo, B. Doehle, S. Sagan and M. Gotte† (2016). A complex network of interactions between S282 and G283 of HCV NS5B and the template strand affect susceptibility to sofosbuvir and ribavirin. Antimicrobial Agents and Chemotherapy 60, 2018-2027. doi: 10.1128/AAC.02436-15
  30. M. Habibian, S. Martinez-Montero, G. Portella, Z. Chua, D.S. Bohle, M. Orozco, and M.J. Damha† (2015). Seven-membered ring nucleoside analogues: stereoselective synthesis and studies on their conformational properties. Organic Letters 17, 5416-5419. doi: 10.1021/acs.orglett.5b02769
  31. N. Tago, A. Katolik, N.E. Clark, E.J. Montemayor, K. Seio, M. Sekine, P.J. Hart, and M.J. Damha† (2015). Design, synthesis and properties of phosphoramidate 2',5'-linked branched RNA: Towards the rational design of inhibitors of the RNA Lariat Debranching Enzyme. Journal of Organic Chemistry 80, 10108-10118. doi: 10.1021/acs.joc.5b01719
  32. K. Yamada, A.S. Wahba, J. Bernatchez, T. Ilina, S. Martinez-Montero, M. Habibian, G.F. Deleavey, M. Gotte, M.A. Parniak, and M.J. Damha† (2015). Nucleotide sugar pucker preference mitigates excision by HIV-1 RT. ACS Chemical Biology 10, 2024-2033. doi: 10.1021/acschembio.5b00263
  33. S. Martinez-Montero, G.F. Deleavey, N. Martin-Pintado, J. Fakhoury, C. Gonzalez, and M.J. Damha† (2015). Locked 2'-deoxy-2',4'-difluororibo modified nucleic acids: thermal stability, structural studies, and siRNA activity. ACS Chemical Biology 10, 2016-2023. doi: 10.1021/acschembio.5b00218
  34. S. Martinez-Montero, G. Deleavey, A. Dierker-Viik, P. Lindovska, T. Ilina, G. Portella, M. Orozco, M.A. Parniak, C. Gonzalez, and M.J. Damha† (2015). Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose modified nucleic acids (2',4'-diFANA). Journal of Organic Chemistry 80, 3083-3091. doi: 10.1021/jo502948t
  35. H. Abou Assi, S. Martinez-Montero, D.M. Dixit, Z. Chua, D.S. Bohle, and M.J. Damha† (2015). Synthesis, structure, and conformational analysis of nucleoside analogues comprising six-membered 1,3-oxathiane sugar rings. European Journal of Organic Chemistry 2005, 1945-1953. doi: 10.1002/ejoc.201403642
  36. J. Lietard, M.R. Hassler, and M.J. Damha† (2014). An orthogonal photolabile linker for the complete "on-support" synthesis/fast deprotection/hybridization of RNA. Chemical Communications 50, 15063-15066. doi: 10.1039/c4cc07153k
  37. J. Lietard, N. Kretschy, M. Sack, A.S. Wahba, M.M. Somoza, and M.J. Damha† (2014). Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography. Chemical Communications 50, 12903-12906. doi: 10.1039/c4cc05771f
  38. M. Yahyaee-Anzahaee, J. Fakhoury, P. Uyen Le, K. Petrecca, and M.J. Damha† (2014). Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity. Nucleic Acid Therapeutics 24, 336-343. doi: 10.1089/nat.2014.0496
  39. E.J. Montemayor, A. Katolik, A.B. Taylor, J. Scheurmann, D.J. Combs, R. Johnsson, S.P. Holloway, S.W. Stevens†, M.J. Damha†, and P.J. Hart† (2014). Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Research 42, 10845-10855. doi: 10.1093/nar/gku725
  40. S.M. Garrey, A. Katolik, M. Prekeris, X. Li, K. York, S. Bernards, S. Fields, R. Zhao, M.J. Damha, and J.R. Hesselberth† (2014). A homolog of lariat debranching enzyme modulates turnover of branched RNA. RNA 20, 1337-1348. doi: 10.1261/rna.044602.114
  41. S. Martinez-Montero, G.F. Deleavey, N. Martin-Pintado, M. Thomson, C. Gonzalez, and M.J. Damha† (2014). Rigid 2',4'-difluororibonucleosides: Synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase. Journal of Organic Chemistry 79, 5627-5635. doi: 10.1021/jo500794v
  42. R.A. Johnsson, J.J. Bogojeski, and M.J. Damha† (2014). An evaluation of selective deprotection conditions for the synthesis of RNA on a light-labile solid support. Bioorganic Medicinal Chemistry Letters 24, 2146-2149. doi: 10.1016/j.bmcl.2014.03.032
  43. A. Katolik, R. Johnsson, E.J Montemayor, P.J. Hart, and M.J. Damha† (2014). Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates. Journal of Organic Chemistry 79, 963-975. doi: 10.1021/jo4024182
  44. A. Dudley, M. Sater, P.U. Le, G. Trinh, M.S. Sadr, J. Bergeron, G.F. Deleavey, B. Bedell, M.J. Damha and K. Petrecca† (2013). DRR regulates Akt activation to drive brain cancer invasion. Oncogene 33, 4952-4960. doi: 10.1038/onc.2013.436
  45. N. Martin-Pintado, G.F. Deleavey, G. Portella, R. Campos-Olivas, M. Orozco, M.J. Damha† and C. Gonzalez† (2013). Backbone FC-H...O hydrogen bonds in 2'F-substituted nucleic acids. Angewandte Chemie Intl. Ed. 52, 12065-12068. doi: 10.1002/anie.201305710
  46. D.P.Y. Chan, G.F. Deleavey, S.C. Owen, M.J. Damha† and M.S. Shoichet† (2013). Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery. Biomaterials 34, 8404-8415. doi: 10.1016/j.biomaterials.2013.07.019
  47. N. Martin-Pintado, M. Yahyaee-Anzahaee, G.F. Deleavey, G. Portella, M. Orozco, M.J. Damha† and C. Gonzalez† (2013). Dramatic effect of furanose C2' substitution on structure and stability: Directing the folding of human telomeric quadruplex with a single fluorine atom. Journal of the American Chemical Society 135, 5344-5347. doi: 10.1021/ja401954t
  48. G.F. Deleavey, F. Frank, M. Hassler, B. Nagar and M.J. Damha† (2013). The 5'-binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues. Nucleic Acid Therapeutics 23, 81-87. doi: 10.1089/nat.2012.0393
  49. N. Souleimanian, G.F. Deleavey, H. Soifer, S. Wang, K. Tiemann, M.J. Damha and C.A. Stein† (2012). Antisense 2'-deoxy-2'-fluoroarabinonucleic acids (2'F-ANAs) antisense oligonucleotides: in vitro gymnotic silencers of gene expression whose potency is enhanced by fatty acids. Molecular Therapy - Nucleic Acids 1, e43. doi: 10.1038/mtna.2012.35
  50. G.F. Deleavey† and M.J. Damha† (2012). Designing chemically modified oligonucleotides for targeted gene silencing. Chemistry & Biology 19, 937-954. doi: 10.1016/j.chembiol.2012.07.011
  51. N. Martin-Pintado, M. Yahyaee-Anzahaee, R. Campos-Olivas, A.M. Noronha, C.J. Wilds, M.J. Damha† and C. Gonzalez† (2012). The solution structure of double helical arabino-nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion. Nucleic Acids Research 40, 9329-9339. doi: 10.1093/nar/gks672
  52. A.E. Felber, N. Bayo-Puxan, G.F. Deleavey, B. Castagner, M.J. Damha† and J.C. Leroux† (2012). The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity. Biomaterials 33, 5955-5965. doi: 10.1016/j.biomaterials.2012.05.019
  53. A.S. Wahba, F. Azizi, G.F. Deleavey, F. Robert, M. Carrier, A. Kalota, A. Gewirtz, J. Pelletier, R.H.E. Hudson and M.J. Damha† (2011). Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. ACS Chemical Biology 6, 912-919. doi: 10.1021/cb200070k
  54. R. Johnsson, J.G. Lackey, J.J. Bogojeski and M.J. Damha† (2011). New light labile linker for solid phase synthesis of 2'-O-acetalester oligonucleotides and applications to siRNA prodrug development. Bioorganic Medicinal Chemistry Letters 21, 3721-3725. doi: 10.1016/j.bmcl.2011.04.073
  55. M. Hassler, Y.Q. Wu, N.M. Reddy, T.H. Chan and M.J. Damha† (2011). RNA synthesis via dimer and trimer phosphoramidite block coupling. Tetrahedron Letters 52, 2575-2578. doi: 10.1016/j.tetlet.2011.03.042
  56. A.E. Felber, B. Castagner, G.F. Deleavey, M. Elsabahy, M.J. Damha and J.-C. Leroux† (2011). siRNA nanocarriers based on methacrylic acid copolymers. Journal of Controlled Release 152, 159-167. doi: 10.1016/j.jconrel.2010.12.012
  57. M. Yahyaee, J.K. Watts, N.R. Alla, A.W. Nicholson and M.J. Damha† (2011). Energetically important C-H...F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity. Journal of the American Chemical Society 133, 728-731. doi: 10.1021/ja109817p
  58. K.T. Gagnon, H. Pendergraff, G.F. Deleavey, E. Swayze, P. Potier, J. Randolph, E.B. Roesch, J. Chattopadhyaya, M.J. Damha, F. Bennett, C. Montaillier, M. Lemaitre, D.R. Corey† (2010). Allele-selective silencing of mutant Huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry 49, 10166-10178. doi: 10.1021/bi101208k
  59. G.F. Deleavey, J.K. Watts, F. Robert, T. Alain, A. Kalota, J. Pelletier, A.M. Gewirtz, N. Sonenberg and M.J. Damha† (2010). Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research 38, 4547-4557. doi: 10.1093/nar/gkq181
  60. J.K. Watts, N. Martin-Pintado, I. Gómez-Pinto, J. Schwartzentruber, G. Portella, M. Orozco, C. González† and M.J. Damha† (2010). Differential stability of 2'F-ANA•RNA and ANA•RNA hybrid duplexes: Roles of structure, pseudohydrogen bonding, hydration, ion uptake, and flexibility. Nucleic Acids Research 38, 2498-2511. doi: 10.1093/nar/gkp1225
  61. G.F. Deleavey, J.K. Watts and M.J. Damha† (2010). Chemical modification of siRNA. Current Protocols in Nucleic Acid Chemistry 39, 16.3.1-22. doi: 10.1002/0471142700.nc1603s39
  62. A.S. Wahba, Arash Ghorbani-Choghamarani, M.J. Damha and R.H.E. Hudson† (2010). A single-label phenylpyrrolo­cytidine provies a molecular beacon-like response reporting HIV-1 RT RNase H activity. Nucleic Acids Research 38, 1048-1056. doi: 10.1093/nar/gkp1022
  63. J.G. Lackey, M.M. Somoza, D. Mitra, F. Cerrina, and M.J. Damha† (2009). In-situ chemical synthesis of rU-DNA chimeras on chips and enzymatic recognition. Chemistry Today 27, 30-33.
  64. M. Elsabahy, N. Wazen, N. Bayó-Puxan, G. Deleavey, M. Servant, M.J. Damha and J.-C. Leroux† (2009). Delivery of nucleic acids through the controlled disassembly of multifunctional nanocomplexes. Advanced Functional Materials 19, 3862-3867. doi: 10.1002/adfm.200901139
  65. J.G. Lackey, D. Mitra, M Somoza, F. Cerrina and M.J. Damha† (2009). Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays. Journal of the American Chemical Society 131, 8496-8502. doi: 10.1021/ja9002074
  66. J.K. Watts, A. Katolik, J. Viladoms and M.J. Damha† (2009). Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA). Organic & Biomolecular Chemistry 7, 1904-1910. doi: 10.1039/b900443b
  67. J.G. Lackey, D. Ron, M.J. Damha, and H.P. Harding† (2008). Toward the discovery of new antifungal agents: The design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p. Nucleic Acids Symposium Series 52, 475-476. doi: 10.1093/nass/nrn241
  68. A.S. Wahba, M.J. Damha and R.H.E. Hudson† (2008). RNA containing pyrrolocytidine base analogs: good binding affinity and fluorescence that responds to hybridization. Nucleic Acids Symposium Series 52, 399-400. doi: 10.1093/nass/nrn203
  69. J.G. Lackey and M.J. Damha† (2008). The acetal levulinyl ester (ALE) group for the 2'-hydroxyl protection of ribonucleosides and the synthesis of oligoribonucleotides. Nucleic Acids Symposium Series 52, 35-36. doi: 10.1093/nass/nrn018
  70. C.G. Peng and M.J. Damha† (2008). Probing DNA polymerase activity with stereoisomeric 2'-fluoro-beta-D-arabinose (2'F-araNTPs) and 2'-fluoro-beta-D-ribose (2'F-rNTPs) nucleoside 5'-triphosphates. Canadian Journal of Chemistry 86, 881-891. doi: 10.1139/v08-089
  71. J.K. Watts†, G.F. Deleavey and M.J. Damha† (2008). Chemically modified siRNA: tools and applications. Drug Discovery Today 13, 842-855. doi: 10.1016/j.drudis.2008.05.007
  72. J.K. Watts, B.D. Johnston, K. Jayakanthan, A.S. Wahba, B.M. Pinto† and M.J. Damha† (2008). Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide. Journal of the American Chemical Society 130, 8578-8579. doi: 10.1021/ja802205u
  73. J.K. Watts and M.J. Damha† (2008). 2'-Fluoroarabinonucleic acids (2'F-ANA): history, properties and new frontiers. Canadian Journal of Chemistry 86, 641-656. doi: 10.1139/v08-049
  74. H.P. Harding,† J.G. Lackey, H-C. Hsu, Y. Zhanga, J. Deng, R-M. Xu, M.J. Damha, and D. Ron (2008). An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. RNA 14, 225-232. doi: 10.1261/rna.859908
  75. D. Mitra and M.J. Damha† (2007). A novel approach to the synthesis of DNA and RNA lariats. Journal of Organic Chemistry 72, 9491-9500. doi: 10.1021/jo701418w
  76. D. Sabatino and M.J. Damha† (2007). Synthesis and properties of oligonucleotides containing a 7-membered (oxepane) sugar ring. Nucleosides, Nucleotides & Nucleic Acids 26, 1185-1188. doi: 10.1080/15257770701527760
  77. C.-G. Peng and M.J. Damha† (2007). DNA polymerase recognition of 2'-deoxy-2'-fluoroarabinonucleoside 5'-triphosphates (2'F-araNTPs). Nucleosides, Nucleotides & Nucleic Acids 26, 1189-1193. doi: 10.1080/15257770701527786
  78. R.A. Donga, M. Hassler, T.-H. Chan and M.J. Damha† (2007). Oligonucleotide synthesis using ionic liquids as soluble supports. Nucleosides, Nucleotides & Nucleic Acids 26, 1287-1293. doi: 10.1080/15257770701530533
  79. C.-G. Peng and M.J. Damha† (2007). G-quadruplex induced stabilization by 2'-deoxy-2'-fluoro-D-arabinonucleic acids (2'F-ANA). Nucleic Acids Research 35, 4977-4988. doi: 10.1093/nar/gkm520
  80. D. Sabatino and M.J. Damha† (2007). Oxepane nucleic acids (ONA): synthesis, characterization and properties of oligonucleotides bearing a seven-membered carbohydrate ring. Journal of the American Chemical Society 129, 8259-8270. doi: 10.1021/ja071336c
  81. R.A. Donga, T.-H. Chan and M.J. Damha† (2007). Ion tagged synthesis of an oligoribonucleotide pentamer: The continuing versatility of TBDMS chemistry. Canadian Journal of Chemistry 85, 272-282. doi: 10.1139/v07-022
  82. C.G. Peng and M.J. Damha† (2007). Polymerase-directed synthesis of 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acids. Journal of the American Chemical Society 129, 5310-5311. doi: 10.1021/ja069100g
  83. J.G. Lackey, D. Sabatino and M.J. Damha† (2007). Solid-phase synthesis and on-column deprotection of RNA from 2'-(and 3'-)O-levulinated (Lv) ribonucleoside monomers. Organic Letters 9, 789-792. doi: 10.1021/ol0629521
  84. J.K. Watts, N. Choubdar, K. Sadalapure, F. Robert, A.S. Wahba, J. Pelletier, B.M. Pinto† and M.J. Damha† (2007). 2'-Fluoro-4'-thioarabino-modified oligonucleotides: Conformational switches linked to siRNA activity. Nucleic Acids Research 35, 1441-1451. doi: 10.1093/nar/gkl1153
  85. B. Patureau, R.H.E. Hudson† and M.J. Damha† (2007). Induction of RNase H activity by arabinose-peptide nucleic acid chimeras. Bioconjugate Chemistry 18, 421-430. doi: 10.1021/bc060300r
  86. J.B. Opalinska, A. Kalota, J. Chattopadhyaya, M.J. Damha and A.M. Gewirtz† (2006). Nucleic acid therapeutics for hematologic malignancies – theoretical considerations. Annals of the New York Academy of Sciences 1082, 124-136. doi: 10.1196/annals.1348.002
  87. N. Ferrari, D. Bergeron, A.-L. Tedeschi, M.M. Mangos, L. Paquet, P.M. Renzi and M.J. Damha† (2006). Characterization of antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA): specificity, potency and duration of activity. Annals of the New York Academy of Sciences 1082, 91-102. doi: 10.1196/annals.1348.032
  88. R.A. Donga, S.M. Khaliq-Uz-Zaman, T.-H. Chan and M.J. Damha† (2006). A novel approach to oligonucleotide synthesis using an imidazolium ion tag as a soluble support. Journal of Organic Chemistry 71, 7907-7910. doi: 10.1021/jo061279q
  89. T. Dowler, D. Bergeron, A.-L. Tedeschi, L. Paquet, N. Ferrari† and M.J. Damha† (2006). Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA). Nucleic Acids Research 34, 1669-1675. doi: 10.1093/nar/gkl033
  90. R. Mourani and M.J. Damha† (2006). Synthesis, characterization and biological properties of small branched RNA fragments containing chiral (Rp and Sp) 2',5'-phosphorothioate linkages. Nucleosides, Nucleotides & Nucleic Acids 25, 203-229. doi: 10.1080/15257770500447004
  91. D. Gendron, S. Carriero, D. Garneau, J. Villemaire, R. Klinck, S. Abou Elela, M.J. Damha† and B. Chabot† (2006). Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals. BMC Biotechnology 6, 5. doi: 10.1186/1472-6750-6-5
  92. A. Kalota, L. Karabon, C Swider, E. Viazovkina, M. Elzagheid, M.J. Damha† and A. Gewirtz† (2006). 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing. Nucleic Acids Research 34, 451-461. doi: 10.1093/nar/gkj455
  93. J.K. Watts, K. Sadalapure, N. Choubdar, B.M. Pinto† and M.J. Damha† (2006). Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU). Journal of Organic Chemistry 71, 921-925. doi: 10.1021/jo051844+
  94. C.-G. Peng and M.J. Damha† (2005). Synthesis and hybridization studies of oligonucleotides containing 1-(2-Deoxy-2-a-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-a-hm-dT). Nucleic Acids Research 33, 7019-7028. doi: 10.1093/nar/gki1003
  95. M. F. Khalid, M.J. Damha, S. Shuman and B. Schwer† (2004). Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic Acids Research 33, 6349-6360. doi: 10.1093/nar/gki934
  96. C.G. Peng, R.N. Hannoush and M.J. Damha† (2004). Synthesis of “taller” 2’,5’-linked ribonucleic acids: 2’-a-C-hydroxymethyl 2’,5’-linked RNA. Journal of Biomolecular Structure & Dynamics 22, 856-857. doi: 10.1080/07391102.2005.10670991
  97. R.N. Hannoush and M.J. Damha† (2004). Preference for ribose over deoxyribose in loop-closing base pairs of extra stable nucleic acid hairpins. Nucleosides, Nucleotides & Nucleic Acids 24, 1519-1530. doi: 10.1080/15257770500265794
  98. R.N. Hannoush, K.-L. Min and M.J. Damha† (2004). Diversity-oriented solid-phase synthesis and biological evaluation of oligonucleotide hairpins as HIV-1 RT RNase H inhibitors. Nucleic Acids Research 32, 6164-6175. doi: 10.1093/nar/gkh948
  99. A. Galarneau, K.-L. Min, M.M. Mangos and M.J. Damha† (2004). Assay for Evaluating Ribonuclease H-mediated Degradation of RNA/antisense oligonucleotide duplexes, in "DNA Synthesis: Methods and Protocols", P. Herdewijn (ed.). Methods in Molecular Biology 288, 65-80. doi: 10.1385%2F1-59259-823-4%3A065
  100. B. Lamontagne, R.N. Hannoush, M.J. Damha and S. Abou-Elela† (2004). Molecular requirements for duplex recognition and cleavage by RNase III: discovery of an RNA-dependent DNA cleavage activity by yeast Rnt1p. Journal of Molecular Biology 338, 401-418. doi: 10.1016/j.jmb.2004.02.059
  101. R. Hannoush, S. Carriero, K.-L. Min and M.J. Damha† (2004). Selective Inhibition of HIV-1 Reverse transcriptase (HIV-1 RT) RNase H by small RNA hairpins and dumbbells. ChemBioChem 5, 527-533. doi: 10.1002/cbic.200300831
  102. S. Carriero and M.J. Damha† (2003). Template-mediated synthesis of lariat DNA and RNA. Journal of Organic Chemistry 68, 8328-8338. doi: 10.1021/jo035002r
  103. S. Carriero and M.J. Damha† (2003). Inhibition of pre-mRNA splicing by synthetic branched nucleic acids. Nucleic Acids Research 31, 6157-6167. doi: 10.1093/nar/gkg824
  104. R.N. Hannoush, A.-Yu. Denisov, K. Gehring and M.J. Damha† (2003). A new RNA fold: RNA hairpins containing unusually stable 2',5'-linked r(UUCG) loops. Journal of Biomolecular Structure & Dynamics 20, 836-837. doi: 10.1021/ja036207k
  105. A.-Y. Denisov, R.N. Hannoush, K. Gehring and M.J. Damha† (2003). A novel RNA motif based on the structure of unusually stable 2',5'-linked r(UUCG) loops. Journal of the American Chemical Society 125, 11525-11531. doi: 10.1021/ja036207k
  106. S. Carriero, M.M. Mangos, K.A. Agha, A.M. Noronha and M.J. Damha† (2003). Branchpoint sugar stereochemistry determines the hydrolytic susceptibility of branched RNA fragments by yDBR. Nucleosides, Nucleotides & Nucleic Acids 22, 1599-1602. doi: 10.1081/NCN-120023043
  107. K.A. Agha and M.J. Damha† (2003). Synthesis and binding properties of a homopyrimidine 2',5'-linked xylose nucleic acid (2',5'-XNA). Nucleosides, Nucleotides & Nucleic Acids 22, 1175-1178. doi: 10.1081/NCN-120022829
  108. R.N. Hannoush, A.Y. Denisov, K. Gehring and M.J. Damha† (2003). Structure of 2',5'-linked tetraribonucleotide loops: a novel RNA motif. Nucleosides, Nucleotides & Nucleic Acids 22, 1687-1690. doi: 10.1081/NCN-120023114
  109. E. Viazovkina, K.-L. Min, A. Galarneau and M.J. Damha† (2003). Synthesis and properties of oligonucleotide chimeras containing 5'-amino-2'-deoxy-2'-fluoroarabinonucleotides. Nucleosides, Nucleotides & Nucleic Acids 22, 1335-1338. doi: 10.1081/NCN-120022959
  110. M. Elzagheid, A.L. Tedeschi and M.J. Damha† (2003). Synthesis of 2',3'-dideoxy-2'-fluoro-3'-thioarabinothymidine and its 3'-phosphoramidite derivative. Nucleosides, Nucleotides & Nucleic Acids 22, 1343-1346. doi: 10.1081/NCN-120022961
  111. E. Viazovkina, M.M. Mangos and M.J. Damha† (2003). Synthesis and properties of 2'-deoxy-2',2"-difluoro-beta-D-ribofuranosyl oligonucleotides and 2'-deoxy-2',2"-difluoro-a-D-ribofuranosyl oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids 22, 1251-1254. doi: 10.1081/NCN-120022848
  112. M. Elzagheid, E. Viazovkina and M.J. Damha† (2003). A new synthesis of 9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)guanine (araF-G). Nucleosides, Nucleotides & Nucleic Acids 22, 1339-1342. doi: 10.1081/NCN-120022960
  113. S. Carriero and M.J. Damha† (2003). Synthesis of lariat-DNA via the chemical ligation of a dumbbell complex. Organic Letters 5, 273-276. doi: 10.1021/ol027227e
  114. M.M. Mangos, K.-L. Min, E. Viazovkina, A. Galarneau, M. Elzagheid, M.A. Parniak and M.J. Damha† (2003). Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts. Journal of the American Chemical Society 125, 654-661. doi: 10.1021/ja025557o
  115. J.Lacombe, E. Viazovkina, P.N. Bernatchez, A. Galarneau, M.J. Damha and Martin G. Sirois† (2002). Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2-fluoro-beta-D-arabino and 2'-deoxynucleosides. Canadian Journal of Physiology and Pharmacology 80, 951-961. doi: 10.1139/y02-123
  116. M.I. Elzagheid, E. Viazovkina, and M.J. Damha† (2002). Synthesis of protected 2'-deoxy-2'-fluoro- beta-D-arabinonucleosides. Current Protocols in Nucleic Acid Chemistry 10, 1.7.1-19. doi: 10.1002/0471142700.nc0107s10
  117. E. Viazovkina, M.M. Mangos, M.I. Elzagheid, and M.J. Damha† (2002). Solid-phase synthesis of 2'-deoxy-2'-fluoro-beta-D-oligoarabinonucleotides (2'F-ANA) and their phosphorothioate derivatives. Current Protocols in Nucleic Acid Chemistry 10, 4.15.1-22. doi: 10.1002/0471142700.nc0415s10
  118. M.M. Mangos and M.J. Damha† (2002). Flexible and frozen sugar-modified nucleic acids - modulation of biological activity through furanose ring dynamics in the antisense strand. Current Topics in Medicinal Chemistry 2, 1145-1169. doi: 10.2174/1568026023393110
  119. K.-L. Min, E. Viazovkina, A. Galarneau, M.A. Parniak,† and M.J. Damha† (2002). Oligonucleotides comprised of alternating 2'-deoxy-2'-fluoro-D-arabinonucleosides and D-2'-deoxyribonucleosides (2'F-ANA/DNA "Altimers"). Bioorganic & Medicinal Chemistry Letters 12, 2651-2654. doi: 10.1016/S0960-894X(02)00439-0
  120. D.R. Yazbeck and M.J.Damha† (2002). Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1. Nucleic Acids Research 30, 3015-3025. doi: 10.1093/nar/gkf429
  121. S. Carriero and M.J. Damha† (2002). Solid-phase synthesis of branched oligonucleotides. Current Protocols in Nucleic Acid Chemistry 9, 4.14.1-32. doi: 10.1002/0471142700.nc0414s09
  122. C.-N. Lok, E. Viazovkina, K.-L. Min, E. Nagy, C.J. Wilds, M.J. Damha† and M.A. Parniak† (2002). Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxynucleotides. Biochemistry 41, 3457-3467. doi: 10.1021/bi0115075
  123. A.Y. Denisov, A.M. Noronha, C.J. Wilds, J.-F. Trempe, R.T. Pon, K. Gehring, and M.J. Damha† (2001). Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'F-ANA/RNA and DNA/RNA hybrids. Nucleic Acids Research 29, 4284-4293. doi: 10.1093/nar/29.21.4284
  124. R. N. Hannoush and M.J. Damha† (2001). Remarkable stability of hairpins containing 2',5'-linked RNA loops. Journal of the American Chemical Society 123, 12368-12374. doi: 10.1021/ja011336r
  125. S.L. Ooi, C. Dann III, K. Nam, D. Leahy, M.J. Damha, J.D. Boeke† (2001). The yeast lariat debranching enzyme, in "Ribonucleases Part A: Functional Roles and Mechanisms". Methods in Enzymology 342, 233-250.
  126. M.J. Damha,† A.M. Noronha, C.J. Wilds, J.F.-Trempe, A. Denisov and K.Gehring (2001). Properties of arabinonucleic acids (ANA & 2'F-ANA): Implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA. Nucleosides, Nucleotides & Nucleic Acids 20, 429-440. doi: 10.1081/NCN-100002317
  127. S. Carriero, R.S. Braich, R.H.E. Hudson, D. Anglin, J.D. Friesen and M.J. Damha† (2001). Inhibition of in-vitro pre-mRNA splicing in S. cerevisiae by branched oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids 20, 873-877. doi: 10.1081/NCN-100002449
  128. R.N. Hannoush and M.J. Damha† (2001). Extra stable 2',5'-linked RNA loops. Nucleosides, Nucleotides & Nucleic Acids 20, 1201-1204. doi: 10.1081/NCN-100002519
  129. A.M. Noronha, D. Arion, M.A. Parniak† and M.J. Damha† (2001). Effect of substituting arabinonucleosides for deoxynucleotides in the DNA priming strand on the polymerase action of HIV-1 RT. Nucleosides, Nucleotides & Nucleic Acids 20, 1205-1209. doi: 10.1081/NCN-100002520
  130. J.F. Trempe, C.J. Wilds, A. Danisov, M.J. Damha† and K. Gehring (2001). NMR structure of a 2'F-ANA/RNA duplex and relevance to the activation of RNaseH. Journal of the American Chemical Society 123, 4896-4903. doi: 10.1021/ja003859p
  131. R.N. Hannoush and M.J. Damha† (2001). Structure and thermodynamics of hairpins containing 2',5'-Linked RNA loops. Journal of Biomolecular Structure & Dynamics 18, 906. doi: 10.1080/07391102.2001.10708253
  132. C.J. Wilds and M.J. Damha† (2000). 2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies. Nucleic Acids Research 28, 3625-3635. doi: 10.1093/nar/28.18.3625
  133. A.M. Noronha, C. J. Wilds, C.N. Lok, K. Viazovkina, D. Arion, M.A. Parniak and M.J. Damha† (2000). Synthesis and biophysical properties of arabinonucleic acids (ANA): CD spectra, melting temperatures, and RNase H susceptibility of ANA/RNA hybrids. Biochemistry 39, 7050-7062. doi: 10.1021/bi000280v
  134. C. J. Wilds and M.J. Damha† (1999). Duplex recognition by oligonucleotides containing 2’-deoxy-2’-fluoro-D-arabinose and 2'-deoxy-2'-fluoro-D-ribose. Intermolecular [2'OH-phosphate] contacts versus sugar puckering in the stabilization of triple helical complexes. Bioconjugate Chemistry 10, 299-305. doi: 10.1021/bc9801171
  135. M.J .Damha,† C. Wilds, A.M. Noronha, I. Brukner, G. Borkow and M.A. Parniak (1998). Hybrids of RNA and arabinonucleic acids (ANA and 2'F-ANA) are substrates of ribonuclease H. Journal of the American Chemical Society 120, 12976-12977. doi: 10.1021/ja982325+
  136. M.J. Damha† and A.M. Noronha (1998). Recognition of nucleic acid double helices by homopyrimidine 2',5'-linked RNA. Nucleic Acids Research 26, 5152-5156. doi: 10.1093/nar/26.22.5152
  137. A.M. Noronha and M.J. Damha† (1998). Triple helices containing arabinonucleotides in the third (Hoogsteen) strand: effects of inverted stereochemistry at the 2’-position of the sugar moiety. Nucleic Acids Research 26, 2665-2671. doi: 10.1093/nar/26.11.2665
  138. M.J. Damha† and R.S. Braich (1998). Synthesis of a branched DNA/RNA chimera similar to the msDNA molecule of Myxococcus xanthus. Tetrahedron Letters 39, 3907-3910. doi: 10.1016/S0040-4039(98)00724-2
  139. M. Wasner, D. Arion, G. Borkow, A. Noronha, A. H. Uddin, M. A. Parniak, and M.J. Damha† (1998). Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA ‘hybrid’ duplexes. Biochemistry 37, 7478-7486. doi: 10.1021/bi980160b
  140. R.H.E. Hudson, S. Robidoux and M.J. Damha† (1998). Divergent synthesis of nucleic acid dendrimers. Tetrahedron Letters 39, 1299-1302. doi: 10.1016/S0040-4039(97)10871-1
  141. S. Robidoux, R. Klinck, K. Gehring, and M.J. Damha† (1997). Association of branched oligonucleotides into the i-motif. Journal of Biomolecular Structure & Dynamics 15, 517-527. doi: 10.1080/07391102.1997.10508962
  142. S. Robidoux and M.J. Damha† (1997). 2-Deoxyribose and arabinose, but not ribose, stabilize the cytosine (I-DNA) structure. Journal of Biomolecular Structure & Dynamics 15, 529-535. doi: 10.1080/07391102.1997.10508963
  143. A.H. Uddin, P.A.E. Piunno, R.H.E. Hudson, M.J. Damha† and U.J. Krull† (1997). A fiber optic biosensor for fluorimetric detection of triple-helical DNA. Nucleic Acids Research 25, 4139-4146. doi: 10.1093/nar/25.20.4139
  144. G. Borkow, D. Arion, A.M. Noronha, M. Scartozzi, M.J. Damha and M.A. Parniak† (1997). Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. International Journal of Biochemistry & Cell Biology 29, 1285-1295. doi: 10.1016/S1357-2725(97)00067-8
  145. C.J. Wilds, J.F. Lunetta, Y.S. Tsantrizos† and M.J. Damha† (1997). Biophysical studies and synthesis of oligonucleotides containing a peptide/aromatic backbone. Journal of Biomolecular Structure & Dynamics 14, 806. doi: 10.1080/07391102.1997.10508179
  146. A. Noronha and M.J. Damha† (1997). Hybridization Properties of Arabinonucleic Acids (ANA): Influence of stereochemistry at 2’ on the stability of double and triple helices. Journal of Biomolecular Structure & Dynamics 14, 805-806. doi: 10.1080/07391102.1997.10508179
  147. M. Wasner, A. Uddin, G. Borkow, D. Arion, M.A. Parniak† and M.J. Damha† (1997). Selective association and antisense properties of 2',5'-linked oligoribonucleotides. Journal of Biomolecular Structure & Dynamics 14, 805. doi: 10.1080/07391102.1997.10508179
  148. S. Robidoux, R. Klinck, K. Gehring, and M.J. Damha† (1997). Association of branched oligonucleotides into C-tetraplexes: 2-deoxyribose and arabinose, but not ribose, stabilize the C-tetrad structure. Journal of Biomolecular Structure & Dynamics 14, 804. doi: 10.1080/07391102.1997.10508179
  149. R.S. Braich and M.J. Damha† (1997). Effect of vicinal 2',5' and 3',5'-phosphodiester linkages on the formation of hairpin DNA. Journal of Biomolecular Structure & Dynamics 14, 803. doi: 10.1080/07391102.1997.10508179
  150. R.S. Braich and M.J. Damha† (1997). Regiospecific solid-phase synthesis of branched oligonucleotides: effect of vicinal 2',5' (or 2',3'-) and 3',5'-phosphodiester linkages on the formation of hairpin DNA. Bioconjugate Chemistry 8, 370-377. doi: 10.1021/bc9700300
  151. P.M. Macdonald†, M.J. Damha†, K. Ganeshan, R. Braich and S.V. Zabarylo (1996). Phosphorus-31 CPMAS NMR characterization of oligonucleotides covalently bound to a solid support. Nucleic Acids Research 24, 2868-2876. doi: 10.1093/nar/24.15.2868
  152. A.H. Uddin, M.A. Roman, J. Anderson and M.J. Damha† (1996). A novel N3-functionalized thymidine linker for the stabilization of triple helical DNA. Chemical Communications 0, 171-172. doi: 10.1039/CC9960000171
  153. R.H.E. Hudson, A. Uddin and M.J. Damha† (1995). Association of branched nucleic acids: Structural and physicochemical analysis of antiparallel T.AT triple-helical DNA. Journal of the American Chemical Society 117, 12470-12477. doi: 10.1021/ja00155a011
  154. M.J. Damha†, B. Meng, C.G. Yannopoulus, D. Wang and G. Just (1995). Structural basis for the RNA selectivity of oligonucleotides containing alkylsulfide internucleoside linkages and 2'-O-substituted 3'-deoxyribose. Nucleic Acids Research 23, 3967-3973. doi: 10.1093/nar/23.19.3967
  155. D. Wang, B. Meng, M.J. Damha and G. Just† (1995). Synthesis of 2'-substituted sulfide-linked dinucleosides. Nucleosides & Nucleotides 14, 1961-1985. doi: 10.1080/15257779508010717
  156. S. Robidoux, Y. Guo and M.J. Damha† (1995). Tricyclic "oxadiazaphosphorine oxide" guanosines: a new strategy to functionalize guanosines at the exocyclic amino group. Tetrahedron Letters 36, 6651-6654. doi: 10.1016/00404-0399(50)1395-X
  157. P.A.E. Piunno, U.J. Krull†, R.H.E. Hudson, M.J. Damha, and H. Cohen (1995). Fiber-optic DNA sensor for fluorimetric nucleic acid determination. Analytical Chemistry 67, 2635-2643. doi: 10.1021/ac00111a022
  158. K. Ganeshan, K. Nam, R.H.E. Hudson, T. Tadey, R. Braich, W.C. Purdy, J.D. Boeke and M.J. Damha† (1995). Novel approaches to the synthesis and analysis of branched RNA. Nucleosides & Nucleotides 14, 1009-1013. doi: 10.1080/15257779508012522
  159. R.H.E. Hudson, K. Ganeshan and M.J. Damha† (1994). Branched Nucleic Acids: Synthesis and Biological Applications, in "Carbohydrate Modifications in Antisense Research", P.D. Cook and Y.S. Sanghvi (eds.). American Chemical Society Symposium Series 580, Chapter 9, 133-152. doi: 10.1021/bk-1994-0580.ch009
  160. K. Nam, R.H.E. Hudson, K. Ganeshan, K.B. Chapman, M.J. Damha† and J.D. Boeke† (1994). Yeast lariat debranching enzyme: substrate and sequence specificity. Journal of Biological Chemistry 269, 20613-20621.
  161. M.J. Damha†, P.A. Giannaris and P. Marfey (1994). Antisense L/D-oligodeoxynucleotide chimeras: Nuclease stability, base-pairing properties, and activity at directing ribonuclease H. Biochemistry 33, 7877-7885. doi: 10.1021/bi00191a015
  162. P.A. Giannaris and M.J. Damha† (1994). Hybridization properties of oligoarabinonucleotides. Canadian Journal of Chemistry 72, 909-918. doi: 10.1139/v94-118
  163. P.A.E. Piunno, U.J. Krull†, R.H.E. Hudson, M.J. Damha, and H. Cohen (1994). Fiber optic biosensor for fluorimetric detection of DNA hybridization. Analytica Chimica Acta 288, 205-214. doi: 10.1016/0003-2670(93)E0611-A
  164. P.A. Giannaris and M.J. Damha† (1993). Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA. Nucleic Acids Research 21, 4742-4749. doi: 10.1093/nar/21.20.4742
  165. I. Idziak, G. Just†, M.J. Damha and P.A. Giannaris (1993). Synthesis and hybridization properties of amide-linked thymidine dimers incorporated into oligodeoxynucleotides. Tetrahedron Letters 34, 5417-5420. doi: 10.1016/S0040-4039(00)73923-2
  166. B. Meng, S.H. Kawai, D. Wang, G. Just†, P.A. Giannaris and M.J. Damha† (1993). A sulfide-incorporating oligonucleotide analogue with selective hybridization properties. Angewandte Chemie Intl. Ed. 32, 729-731. doi: 10.1002/anie.199307291
  167. R.H.E. Hudson and M.J. Damha† (1993). Nucleic acid dendrimers: Novel biopolymer structures. Journal of the American Chemical Society 115, 2119-2124. doi: 10.1021/ja00059a004
  168. S.H. Kawai, D. Wang, P.A. Giannaris, M.J. Damha† and G. Just (1993). Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides. Nucleic Acids Research 21, 1473-1479. doi: 10.1093/nar/21.6.1473
  169. M.J. Damha† and K.K. Ogilvie† (1993). Oligoribonucleotide Synthesis - The Silyl Phosphoramidite Method, in "Protocols for Oligonucleotides and Analogs: Synthesis and Properties", S. Agrawal (ed.). Methods in Molecular Biology 20, 81-114. doi: 10.1385/0-89603-281-7:81
  170. R.H.E. Hudson and M.J. Damha† (1993). Association of branched nucleic acids. Nucleic Acids Symposium Series 21, 97-99.
  171. M.J. Damha†, K. Ganeshan, R.H.E. Hudson and S.V. Zabarylo (1992). Solid-phase synthesis of branched oligoribonucleotides related to mRNA splicing intermediates. Nucleic Acids Research 20, 6565-6573. doi: 10.1093/nar/20.24.6565
  172. M.J. Damha†, Y. Guo, S.V. Zabarylo, K. Ganeshan and P.A. Giannaris (1992). Tricyclic "oxadiazaphosphorine oxide" guanosines: a new strategy to the protection of guanine bases during RNA synthesis. Tetrahedron Letters 33, 6739-6743. doi: 10.1016/S0040-4039(00)61764-1
  173. P.A. Giannaris and M.J. Damha† (1992). Binding properties of 2',5'-linked oligoribonucleotides: evolutionary selection for the 3',5'-phosphodiester bonds in ribonucleic acids. Proceedings of the 10th Annual Graduate Students Symposium (SUNY at Buffalo, New York). 22-30.
  174. M.J. Damha†, P.A. Giannaris, P. Marfey and L.S. Reid (1991). Oligodeoxynucleotides containing unnatural L-2'-deoxyribose. Tetrahedron Letters 32, 2573-2576. doi: 10.1016/S0040-4039(00)78788-0
  175. M.J. Damha†, P.A. Giannaris and N. Kahn (1991). 2',5'-Linked oligoribonucleotides form stable complexes with complementary RNA and DNA. Nucleic Acids Symposium Series 24, 290.
  176. M.J. Damha†, R.H.E. Hudson, K. Ganeshan, S.V. Zabarylo, and Y. Guo (1991). Synthesis and properties of branched and hyperbranched oligonucleotides. Nucleic Acids Symposium Series 24, 203-204.
  177. M.J. Damha, P.A. Giannaris and S.V. Zabarylo (1990). An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis. Nucleic Acids Research 18, 3813-3821. doi: 10.1093/nar/18.13.3813
  178. F. Lafortune, M.J. Damha, X. Tang, K.G. Standing, J.B. Westmore and K.K. Ogilvie (1990). Time-of-flight secondary ion mass spectrometry of branched RNA fragments. Nucleosides & Nucleotides 9, 445-446.
  179. M.J. Damha and S.V. Zabarylo (1989). Automated solid-phase synthesis of branched oligonucleotides. Tetrahedron Letters 30, 6295-6298. doi: 10.1016/S0040-4039(01)93876-6
  180. M.J. Damha, N. Usman and K.K. Ogilvie (1989). Solution and solid-phase synthesis of arabinonucleotides. Canadian Journal of Chemistry 67, 831-837. doi: 10.1139/v89-129
  181. F. Lafortune, W. Ens, K.G. Standing, J.B. Westmore, M.J. Damha and K.K. Ogilvie (1989). Time-of-flight secondary ion mass spectrometry of protected isomeric oligonucleotides. Advances in Mass Spectrometry 11, 1402-1403.
  182. M.J. Damha (1989). Developments in the chemical synthesis of oligonucleotides and their analogues. Ph.D. Thesis (Supervisor: Kelvin K. Ogilvie) McGill University, Montreal, QC, Canada.
  183. M.J. Damha and K.K. Ogilvie (1988). Conformational properties of branched RNA fragments in aqueous solution. Biochemistry 27, 6403-6416. doi: 10.1021/bi00417a032
  184. M.J. Damha and K.K. Ogilvie (1988). Synthesis and spectroscopic analysis of branched RNA fragments: mRNA splicing intermediates. Journal of Organic Chemistry 53, 3710-3722. doi: 10.1021/jo00251a010
  185. F. Lafortune, K.G. Standing, J.B. Westmore, M.J. Damha and K.K. Ogilvie (1988). Differentiation between protected diastereomeric trinucleotides by time-of-flight SIMS. Organic Mass Spectrometry 23, 228-230. doi: 10.1002/oms.1210230314
  186. M.J. Damha, N. Usman and K.K. Ogilvie (1987). The rapid chemical synthesis of arabinonucleotides. Tetrahedron Letters 28, 1633-1636. doi: 10.1016/S0040-4039(00)95378-4
  187. K.K. Ogilvie, M.J. Damha, N. Usman and R.T. Pon (1987). Developments in the chemical synthesis of naturally occurring DNA and RNA with normal and unusual linkages. Pure & Applied Chemistry 28, 325. doi: 10.1351/pac198759030325
  188. R.T. Pon, N. Usman, M.J. Damha and K.K. Ogilvie† (1986). Prevention of guanine modification and chain cleavage during the solid-phase synthesis of oligonucleotides using phosphoramidite derivatives. Nucleic Acids Research 14, 6453-6470. doi: 10.1093/nar/14.16.6453
  189. M.J. Damha and K.K. Ogilvie† (1986). Modification of guanine bases: reaction of N2-acylated guanine nucleosides with dichloro-N,N-diisopropylaminophosphine. Journal of Organic Chemistry 51, 3559-3560. doi: 10.1021/jo00368a037
  190. R.T. Pon, M.J. Damha and K.K. Ogilvie (1985). Modification of guanine bases by nucleoside phosphoramidite reagents during the solid-phase synthesis of oligonucleotides. Nucleic Acids Research 13, 6447-6465. doi: 10.1093/nar/13.18.6447
  191. M.J. Damha, R.T. Pon and K.K. Ogilvie (1985). Chemical synthesis of branched RNA: novel trinucleoside diphosphates containing vicinal 2′,5′- and 3′,5′-phosphodiester linkages. Tetrahedron Letters 26, 4839-4842. doi: 10.1016/S0040-4039(00)94965-7
  192. R.T. Pon, M.J. Damha and K.K. Ogilvie (1985). Necessary protection of the 06-position of guanine during the solid-phase synthesis of oligonucleotides by the amidite approach. Tetrahedron Letters 26, 2525-2528. doi: 10.1016/S0040-4039(00)98827-0

PATENTS

  1. Nucleic acid biosensor diagnostics. Inventors: U.J. Krull, P.A. Piunno, R.H. Hudson, A.H. Uddin, M.J. Damha; WO9858079; Nationalized in US 6,503,711; AU 755913; NZ 520303.
  2. Antisense oligonucleotide constructs based on arabinose and its analogues. Inventors: M.J. Damha, M.A. Parniak, A. Noronha, C.J. Wilds, D. Arion, G. Borkow; WO 9967378 (priority date: 19-06-1998); Nationalized in CA 2,331,333; 2,241,361; EU 99 928945.7; US 09/19,870.
  3. Chimeric antisense of arabinofuranose and deoxyribose nucleotides. Inventors: M.J. Damha, M.A. Parniak, C.-N. Lok, K. Viazovkina; Provisional application US 60/230,414 filed Sept. 6, 2000; WO 02020773; Nationalized in CA 2,419,563; SE 1969101.3; IT 1969101.3; NZ 0534396A; US 10/263,768, US 60/230,414; EU 01969191.3; AU 2001289448; JP 2002-525780.
  4. Acyclic linker-containing oligonucleotides and uses thereof. Inventors: M.J. Damha, M.A. Parniak, M.M. Mangos, K.-L. Min, K. Viazovkina; Provisional application US 60/330,719 filed Oct. 29, 2001; WO 03037909; Nationalized in CA 2,465,129; DE 002060216798; NZ 532610; EP1440079B1; MX20004004056-A1; AU 2002/335,954; JP 2003-540190; US 10.494,141.
  5. Oligonucleotides comprising alternating segments and uses thereof. Inventors: M.J. Damha, M.A. Parniak; Provisional application US 60/352,873 filed January 31, 2002; WO 03064441; Nationalized in CA 2,474,414; NZ 534,396; AU 2003/202376; EP 3700774.7; JP 2003-564061; MX PA/a/2004/00; US 10/503,120.
  6. Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase. Inventors: M.J. Damha, R.N. Hannoush, K.-L. Min S. Carriero; Provisional application US 60/437,568 filed Dec. 12, 2002; US7501503 B2.
  7. Ionic liquid supported synthesis. Inventors: T.-H. Chan, M.J. Damha, R.A. Donga, X. He, W. Miao; Provisional application US60/661,480 filed March 15, 2005; WO2006096963 A1; Nationalized in EP 06705308.2; JP 2008-501121; US 11/980,487; IN 3623/KOLNP/2007; CN 200680016812.9.
  8. Aptamers comprising arabinose modified nucleotides. Inventors: M.J. Damha, C.-G. Peng. Provisional application US60/722,973 filed Oct. 10, 2005; WO2007038869 A1.
  9. 4'-Thioarabinonucleotide containing oligonucleotides, compounds and methods for their preparation and uses thereof. Inventors: M.J. Damha, J.K. Watts, B.M. Pinto; Provisional application US 60/750,838 filed Dec. 16, 2005; WO 2007068113.
  10. 2'-Deoxy-2'-fluoro-beta-D-arabinonucleoside 5'-triphosphates and their use in enzymatic nucleic acid synthesis. Inventors: M.J. Damha, C.G. Peng; Provisional application US 60/839,417 filed Aug. 23, 2006; WO 2008022469.
  11. Oxepane nucleosides and oligonucleotides, uses thereof and methods of making the same. Inventors: M.J. Damha, D. Sabatino; Provisional application US60/841,203 filed Aug. 31, 2006; WO2008025160.
  12. Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof. Inventors: M.J. Damha, J.K. Watts & Glen F. Deleavey; Provisional application US61/059,186 filed 05-06-2008; WO2009146556 A1.
  13. Oligonucleotide Duplexes Comprising DNA-like and RNA-like Nucleotides and Uses Thereof. Inventors: Damha, M. J., Watts, J. K., Deleavey, G. F.; PCT/CA2009/000789 filed June 5, 2008;WO2009146556.
  14. Immune Response Modulation and Uses Thereof. Inventors: Sonenberg, N., Costa-Mattioli, M., Colina Munoz, H. R., Svitkin, I. V., Alain, T., Damha, M. J., Deleavey, G. F.; PCT/CA2008/002259 filedDec. 19, 2007; WO2009076775.
  15. RNA monomers containing O-acetal levulinyl ester groups and their use in RNA microarrays. Inventors: F. Cerrina, D. Mitra, M. Wickens, M.J. Damha, J.G. Lackey, A. Ansari; Provisional application US61/094,525 filed 9/8/2008; WO2010025566 A1.
  16. Method for Reducing Expression of Downregulated in Renal Cell Carcinoma in Malignant Gliomas. Inventors: K. Petrecca, M.J. Damha, D.G. Deleavey; Provisional application US 20130197057 A1 filed May 18, 2010; CN103370414A, EP2571989A1, WO2011143762A1.
  17. Block synthesis of oligoribonucleotides. Inventors: M.J. Damha, M.Hassler, T.-H. Chan, N.M. Reddy, R.A. Donga; Provisional application EP 2609107A1 filed 22/8/2010; WO2012024776A1.